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Start of funding 01.01.2009
"Filming" structural changes of light-activated proteins using pulsed electron spin resonance
Prof. Dr. Steffen J. Glaser
Technische Universität München
Prof. Dr. Song-I Han
University of California, Santa Barbara
Dept. of Chemistry and Biochemistry
The goal of the cooperation is to follow the photocycle of light-
activated proteins. In particular, spin-labeled proteorhodopsin will
be studied, which is the most prevalent proton-pump of the ocean
biosphere. The photocycle has a duration of about 20 ms and the goal
is to detect structural changes with a time resolution of about 100
ns or less using pulsed electron spin resonance. This requires the
combined development of new ESR hardware with pulse durations on the
order of nano seconds, optimal ESR pulse sequences, and theoretical
tools to translate the transient spectra into a “film” of the
structural changes of proteorhodopsin upon light activation with sub
milli second resolution.