Subsequent projects

Prof. Dr. Paul Steinmann
Friedrich-Alexander-University of
Technische Mechanik

Prof. Dr. Ellen Kuhl
Stanford University
Department of Mechanical Engineering

Mechanical Characterization of Brain Development

Disclosing the origin of convolutions in the mammalian brain remains a scientific challenge. Malformations originating from early stages of development are associated with neurological disorders such as schizophrenia and autism. Recent evidence suggests that mechanics play a crucial role during brain development. The establishment of an effective mechanical model requires experimentally determined material parameters. Controversies regarding both the underlying mechanism of brain folding and the material properties of brain tissue have caused ongoing debate. Reported stiffness values vary by an order of magnitude or more.  Furthermore, mechanical testing of brain tissue has so far been limited to fully developed brains, whose cellular microstructure differs significantly from that of brains in the immature developmental stage. We will combine continuum modeling and simulation with mechanical testing of brain tissue to clarify the role of mechanics during brain development and improves our understanding of normal and abnormal brain structure with its associated neurological disorders.


Primary project: Multi-Scale Modelling and Simulation of Higher Order Continuum Models of Diffusion


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